Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death

Mutations of Fused in sarcoma (FUS), a ribonucleoprotein involved in RNA metabolism, have been found associated with both familial and sporadic cases of amyotrophic lateral sclerosis (ALS). Notably, besides mutations in the coding sequence, also mutations into the 3′ untranslated region, leading to...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Ajmone-Cat, Maria Antonietta, Onori, Angela, Toselli, Camilla, Stronati, Eleonora, Morlando, Mariangela, Bozzoni, Irene, Monni, Emanuela, Kokaia, Zaal, Lupo, Giuseppe, Minghetti, Luisa, Biagioni, Stefano, Cacci, Emanuele
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418113/
https://ncbi.nlm.nih.gov/pubmed/30872738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41040-4
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