Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death

Mutations of Fused in sarcoma (FUS), a ribonucleoprotein involved in RNA metabolism, have been found associated with both familial and sporadic cases of amyotrophic lateral sclerosis (ALS). Notably, besides mutations in the coding sequence, also mutations into the 3′ untranslated region, leading to...

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Vydáno v:Sci Rep
Hlavní autoři: Ajmone-Cat, Maria Antonietta, Onori, Angela, Toselli, Camilla, Stronati, Eleonora, Morlando, Mariangela, Bozzoni, Irene, Monni, Emanuela, Kokaia, Zaal, Lupo, Giuseppe, Minghetti, Luisa, Biagioni, Stefano, Cacci, Emanuele
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418113/
https://ncbi.nlm.nih.gov/pubmed/30872738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41040-4
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