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Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death

Mutations of Fused in sarcoma (FUS), a ribonucleoprotein involved in RNA metabolism, have been found associated with both familial and sporadic cases of amyotrophic lateral sclerosis (ALS). Notably, besides mutations in the coding sequence, also mutations into the 3′ untranslated region, leading to...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ajmone-Cat, Maria Antonietta, Onori, Angela, Toselli, Camilla, Stronati, Eleonora, Morlando, Mariangela, Bozzoni, Irene, Monni, Emanuela, Kokaia, Zaal, Lupo, Giuseppe, Minghetti, Luisa, Biagioni, Stefano, Cacci, Emanuele
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418113/
https://ncbi.nlm.nih.gov/pubmed/30872738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41040-4
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