Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death

Mutations of Fused in sarcoma (FUS), a ribonucleoprotein involved in RNA metabolism, have been found associated with both familial and sporadic cases of amyotrophic lateral sclerosis (ALS). Notably, besides mutations in the coding sequence, also mutations into the 3′ untranslated region, leading to...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Ajmone-Cat, Maria Antonietta, Onori, Angela, Toselli, Camilla, Stronati, Eleonora, Morlando, Mariangela, Bozzoni, Irene, Monni, Emanuela, Kokaia, Zaal, Lupo, Giuseppe, Minghetti, Luisa, Biagioni, Stefano, Cacci, Emanuele
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418113/
https://ncbi.nlm.nih.gov/pubmed/30872738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41040-4
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