Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent

Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as well as plasmid-mediated class A β-lactamases....

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Pubblicato in:mBio
Autori principali: Barnes, Melissa D., Kumar, Vijay, Bethel, Christopher R., Moussa, Samir H., O’Donnell, John, Rutter, Joseph D., Good, Caryn E., Hujer, Kristine M., Hujer, Andrea M., Marshall, Steve H., Kreiswirth, Barry N., Richter, Sandra S., Rather, Philip N., Jacobs, Michael R., Papp-Wallace, Krisztina M., van den Akker, Focco, Bonomo, Robert A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414696/
https://ncbi.nlm.nih.gov/pubmed/30862744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00159-19
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