Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent

Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as well as plasmid-mediated class A β-lactamases....

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Publicado no:mBio
Main Authors: Barnes, Melissa D., Kumar, Vijay, Bethel, Christopher R., Moussa, Samir H., O’Donnell, John, Rutter, Joseph D., Good, Caryn E., Hujer, Kristine M., Hujer, Andrea M., Marshall, Steve H., Kreiswirth, Barry N., Richter, Sandra S., Rather, Philip N., Jacobs, Michael R., Papp-Wallace, Krisztina M., van den Akker, Focco, Bonomo, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414696/
https://ncbi.nlm.nih.gov/pubmed/30862744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00159-19
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