Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent

Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as well as plasmid-mediated class A β-lactamases....

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Udgivet i:mBio
Main Authors: Barnes, Melissa D., Kumar, Vijay, Bethel, Christopher R., Moussa, Samir H., O’Donnell, John, Rutter, Joseph D., Good, Caryn E., Hujer, Kristine M., Hujer, Andrea M., Marshall, Steve H., Kreiswirth, Barry N., Richter, Sandra S., Rather, Philip N., Jacobs, Michael R., Papp-Wallace, Krisztina M., van den Akker, Focco, Bonomo, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414696/
https://ncbi.nlm.nih.gov/pubmed/30862744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00159-19
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