Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent

Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as well as plasmid-mediated class A β-lactamases....

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Veröffentlicht in:mBio
Hauptverfasser: Barnes, Melissa D., Kumar, Vijay, Bethel, Christopher R., Moussa, Samir H., O’Donnell, John, Rutter, Joseph D., Good, Caryn E., Hujer, Kristine M., Hujer, Andrea M., Marshall, Steve H., Kreiswirth, Barry N., Richter, Sandra S., Rather, Philip N., Jacobs, Michael R., Papp-Wallace, Krisztina M., van den Akker, Focco, Bonomo, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414696/
https://ncbi.nlm.nih.gov/pubmed/30862744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00159-19
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