Frequency and Mechanism of Spontaneous Resistance to Sulbactam Combined with the Novel β-Lactamase Inhibitor ETX2514 in Clinical Isolates of Acinetobacter baumannii

The novel diazabicyclooctenone ETX2514 is a potent, broad-spectrum serine β-lactamase inhibitor that restores sulbactam activity against resistant Acinetobacter baumannii. The frequency of spontaneous resistance to sulbactam-ETX2514 in clinical isolates was found to be 7.6 × 10(−10) to <9.0 × 10(...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: McLeod, Sarah M., Shapiro, Adam B., Moussa, Samir H., Johnstone, Michele, McLaughlin, Robert E., de Jonge, Boudewijn L. M., Miller, Alita A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786785/
https://ncbi.nlm.nih.gov/pubmed/29133555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01576-17
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