SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1

BACKGROUND: Programmed death-ligand 1 (PD-L1) is a T-cell inhibitory checkpoint molecule that suppresses antitumor immunity. Anti-PD-L1 antibodies have shown remarkable promise in treating tumors, but the patient response rate is low. Therefore, small-molecule checkpoint inhibitors blocking PD-L1 fu...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Zhang, Na, Dou, Yueying, Liu, Lu, Zhang, Xin, Liu, Xiaojia, Zeng, Qingxuan, Liu, Yang, Yin, Mingxiao, Liu, Xiujun, Deng, Hongbin, Song, Danqing
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414307/
https://ncbi.nlm.nih.gov/pubmed/30711516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.01.054
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