The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling

Quetiapine, one of the most prescribed atypical antipsychotics, has been associated with hyperlipidemia and an increased risk for cardiovascular disease in patients, but the underlying mechanisms remain unknown. Here, we identified quetiapine as a potent and selective agonist for pregnane X receptor...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Meng, Zhaojie, Gwag, Taesik, Sui, Yipeng, Park, Se-Hyung, Zhou, Xiangping, Zhou, Changcheng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413802/
https://ncbi.nlm.nih.gov/pubmed/30728326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125657
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