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The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling
Quetiapine, one of the most prescribed atypical antipsychotics, has been associated with hyperlipidemia and an increased risk for cardiovascular disease in patients, but the underlying mechanisms remain unknown. Here, we identified quetiapine as a potent and selective agonist for pregnane X receptor...
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| Publicado en: | JCI Insight |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6413802/ https://ncbi.nlm.nih.gov/pubmed/30728326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125657 |
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