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The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling
Quetiapine, one of the most prescribed atypical antipsychotics, has been associated with hyperlipidemia and an increased risk for cardiovascular disease in patients, but the underlying mechanisms remain unknown. Here, we identified quetiapine as a potent and selective agonist for pregnane X receptor...
Guardat en:
| Publicat a: | JCI Insight |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6413802/ https://ncbi.nlm.nih.gov/pubmed/30728326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125657 |
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