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The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling
Quetiapine, one of the most prescribed atypical antipsychotics, has been associated with hyperlipidemia and an increased risk for cardiovascular disease in patients, but the underlying mechanisms remain unknown. Here, we identified quetiapine as a potent and selective agonist for pregnane X receptor...
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| 出版年: | JCI Insight |
|---|---|
| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6413802/ https://ncbi.nlm.nih.gov/pubmed/30728326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125657 |
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