Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice

Plexiform neurofibroma is a major contributor to morbidity in patients with neurofibromatosis type I (NF1). Macrophages and mast cells infiltrate neurofibroma, and data from mouse models implicate these leukocytes in neurofibroma development. Antiinflammatory therapy targeting these cell populations...

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Udgivet i:JCI Insight
Main Authors: Fletcher, Jonathan S., Wu, Jianqiang, Jessen, Walter J., Pundavela, Jay, Miller, Jacob A., Dombi, Eva, Kim, Mi-Ok, Rizvi, Tilat A., Chetal, Kashish, Salomonis, Nathan, Ratner, Nancy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413799/
https://ncbi.nlm.nih.gov/pubmed/30728335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98601
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