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Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation
Systemic inflammation is central to aging‐related conditions. However, the intrinsic factors that induce inflammation are not well understood. We previously identified a cell‐autonomous pathway through which damaged nuclear DNA is trafficked to the cytosol where it activates innate cytosolic DNA sen...
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| Pubblicato in: | Aging Cell |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6413746/ https://ncbi.nlm.nih.gov/pubmed/30706626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12901 |
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