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Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
Deficiencies in DNA degrading nucleases lead to accumulation of self DNA and induction of autoimmunity in mice and in monogenic and polygenic human diseases. However, the sources of DNA and the mechanisms that trigger immunity remain unclear. We analyzed mice deficient for the lysosomal nuclease, Dn...
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| Veröffentlicht in: | Cell Rep |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4555847/ https://ncbi.nlm.nih.gov/pubmed/25284779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.074 |
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