Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

Diverse causes, including pathogenic invasion or the uptake of mineral crystals such as silica and monosodium urate (MSU), threaten cells with lysosomal rupture, which can lead to oxidative stress, inflammation, and apoptosis or necrosis. Here, we demonstrate that lysosomes are selectively sequester...

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Hlavní autoři: Maejima, Ikuko, Takahashi, Atsushi, Omori, Hiroko, Kimura, Tomonori, Takabatake, Yoshitsugu, Saitoh, Tatsuya, Yamamoto, Akitsugu, Hamasaki, Maho, Noda, Takeshi, Isaka, Yoshitaka, Yoshimori, Tamotsu
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770333/
https://ncbi.nlm.nih.gov/pubmed/23921551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.171
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