Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

Diverse causes, including pathogenic invasion or the uptake of mineral crystals such as silica and monosodium urate (MSU), threaten cells with lysosomal rupture, which can lead to oxidative stress, inflammation, and apoptosis or necrosis. Here, we demonstrate that lysosomes are selectively sequester...

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Bibliografiske detaljer
Main Authors: Maejima, Ikuko, Takahashi, Atsushi, Omori, Hiroko, Kimura, Tomonori, Takabatake, Yoshitsugu, Saitoh, Tatsuya, Yamamoto, Akitsugu, Hamasaki, Maho, Noda, Takeshi, Isaka, Yoshitaka, Yoshimori, Tamotsu
Format: Artigo
Sprog:Inglês
Udgivet: European Molecular Biology Organization 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770333/
https://ncbi.nlm.nih.gov/pubmed/23921551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.171
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