High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

Excessive fat intake contributes to the progression of metabolic diseases via cellular injury and inflammation, a process termed lipotoxicity. Here, we investigated the role of lysosomal dysfunction and impaired autophagic flux in the pathogenesis of lipotoxicity in the kidney. In mice, a high-fat d...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Yamamoto, Takeshi, Takabatake, Yoshitsugu, Takahashi, Atsushi, Kimura, Tomonori, Namba, Tomoko, Matsuda, Jun, Minami, Satoshi, Kaimori, Jun-ya, Matsui, Isao, Matsusaka, Taiji, Niimura, Fumio, Yanagita, Motoko, Isaka, Yoshitaka
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2017
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407727/
https://ncbi.nlm.nih.gov/pubmed/27932476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016070731
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