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Autophagosome–lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome

Autophagy is a multistep membrane traffic pathway. In contrast to autophagosome formation, the mechanisms underlying autophagosome–lysosome fusion remain largely unknown. Here, we describe a novel autophagy regulator, inositol polyphosphate‐5‐phosphatase E (INPP5E), involved in autophagosome–lysosom...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Hasegawa, Junya, Iwamoto, Ryo, Otomo, Takanobu, Nezu, Akiko, Hamasaki, Maho, Yoshimori, Tamotsu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007553/
https://ncbi.nlm.nih.gov/pubmed/27340123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593148
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