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Regulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome–lysosome fusion

Macroautophagy (autophagy) is a multistep intracellular degradation system. Autophagosomes form, mature, and ultimately fuse with lysosomes, where their sequestered cargo molecules are digested. In contrast to autophagosome formation, our knowledge of autophagosome-lysosome fusion is limited. In a r...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Nakamura, Shuhei, Hasegawa, Junya, Yoshimori, Tamotsu
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173256/
https://ncbi.nlm.nih.gov/pubmed/27715391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1234568
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