Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy

Deficiencies in DNA degrading nucleases lead to accumulation of self DNA and induction of autoimmunity in mice and in monogenic and polygenic human diseases. However, the sources of DNA and the mechanisms that trigger immunity remain unclear. We analyzed mice deficient for the lysosomal nuclease, Dn...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Lan, Yuk Yuen, Londoño, Diana, Bouley, Richard, Rooney, Michael S., Hacohen, Nir
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555847/
https://ncbi.nlm.nih.gov/pubmed/25284779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.074
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