Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

Systemic inflammation is central to aging‐related conditions. However, the intrinsic factors that induce inflammation are not well understood. We previously identified a cell‐autonomous pathway through which damaged nuclear DNA is trafficked to the cytosol where it activates innate cytosolic DNA sen...

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Bibliographic Details
Published in:Aging Cell
Main Authors: Lan, Yuk Yuen, Heather, James M., Eisenhaure, Thomas, Garris, Christopher Stuart, Lieb, David, Raychowdhury, Raktima, Hacohen, Nir
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Original Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413746/
https://ncbi.nlm.nih.gov/pubmed/30706626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12901
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