Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells

Human induced pluripotent stem cells (iPSCs) hold enormous promise for regenerative medicine. The major safety concern is the tumorigenicity of transplanted cells derived from iPSCs. A potential solution would be to introduce a suicide gene into iPSCs as a safety switch. The herpes simplex virus typ...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Autores principales: Iwasawa, Chizuru, Tamura, Ryota, Sugiura, Yuki, Suzuki, Sadafumi, Kuzumaki, Naoko, Narita, Minoru, Suematsu, Makoto, Nakamura, Masaya, Yoshida, Kazunari, Toda, Masahiro, Okano, Hideyuki, Miyoshi, Hiroyuki
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413063/
https://ncbi.nlm.nih.gov/pubmed/30769780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20040810
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