Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells

Human induced pluripotent stem cells (iPSCs) hold enormous promise for regenerative medicine. The major safety concern is the tumorigenicity of transplanted cells derived from iPSCs. A potential solution would be to introduce a suicide gene into iPSCs as a safety switch. The herpes simplex virus typ...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Iwasawa, Chizuru, Tamura, Ryota, Sugiura, Yuki, Suzuki, Sadafumi, Kuzumaki, Naoko, Narita, Minoru, Suematsu, Makoto, Nakamura, Masaya, Yoshida, Kazunari, Toda, Masahiro, Okano, Hideyuki, Miyoshi, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413063/
https://ncbi.nlm.nih.gov/pubmed/30769780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20040810
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