Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells

Human induced pluripotent stem cells (iPSCs) hold enormous promise for regenerative medicine. The major safety concern is the tumorigenicity of transplanted cells derived from iPSCs. A potential solution would be to introduce a suicide gene into iPSCs as a safety switch. The herpes simplex virus typ...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Iwasawa, Chizuru, Tamura, Ryota, Sugiura, Yuki, Suzuki, Sadafumi, Kuzumaki, Naoko, Narita, Minoru, Suematsu, Makoto, Nakamura, Masaya, Yoshida, Kazunari, Toda, Masahiro, Okano, Hideyuki, Miyoshi, Hiroyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413063/
https://ncbi.nlm.nih.gov/pubmed/30769780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20040810
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