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Prodrugs of herpes simplex thymidine kinase inhibitors
BACKGROUND: Because guanine-based herpes simplex virus thymidine kinase inhibitors are not orally available, we synthesized various 6-deoxy prodrugs of these compounds and evaluated them with regard to solubility in water, oral bioavailability, and efficacy to prevent herpes simplex virus-1 reactiva...
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Publicado no: | Antivir Chem Chemother |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
SAGE Publications
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5890518/ https://ncbi.nlm.nih.gov/pubmed/26463822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040206615608722 |
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