Prodrugs of herpes simplex thymidine kinase inhibitors

BACKGROUND: Because guanine-based herpes simplex virus thymidine kinase inhibitors are not orally available, we synthesized various 6-deoxy prodrugs of these compounds and evaluated them with regard to solubility in water, oral bioavailability, and efficacy to prevent herpes simplex virus-1 reactiva...

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Détails bibliographiques
Publié dans:Antivir Chem Chemother
Auteurs principaux: Yanachkova, Milka, Xu, Wei-Chu, Dvoskin, Sofya, Dix, Edward J, Yanachkov, Ivan B, Focher, Federico, Savi, Lida, Sanchez, M Dulfary, Foster, Timothy P, Wright, George E
Format: Artigo
Langue:Inglês
Publié: SAGE Publications 2015
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890518/
https://ncbi.nlm.nih.gov/pubmed/26463822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040206615608722
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