N(2)-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases

Herpes simplex virus (HSV) types 1 and 2 thymidine kinases (TK) are responsible for phosphorylation of antiherpes acyclonucleosides such as acyclovir (ACV) and 9-(4-hydroxybutyl)guanine (HBG). Related compounds, the N(2)-phenyl-9-(hydroxyalkyl)guanines, are devoid of direct antiviral activity, but p...

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Hlavní autoři: Lossani, Andrea, Savi, Lida, Manikowski, Andrzej, Maioli, Andrew, Gambino, Joseph, Focher, Federico, Spadari, Silvio, Wright, George E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984574/
https://ncbi.nlm.nih.gov/pubmed/24734222
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