Kinetic studies with N2-phenylguanines and with L-thymidine indicate that herpes simplex virus type-1 thymidine kinase and thymidylate kinase share a common active site.

Lignende værker

• Prodrugs of herpes simplex thymidine kinase inhibitors
  af: Yanachkova, Milka, et al.
  Udgivet: (2015)
• Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate.
  af: Focher, F, et al.
  Udgivet: (1995)
• Lack of stereospecificity of suid pseudorabies virus thymidine kinase.
  af: Maga, G, et al.
  Udgivet: (1993)
• N(2)-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases
  af: Lossani, Andrea, et al.
  Udgivet: (2012)
• Inhibition of Herpes Simplex Virus Thymidine Kinases by 2-Phenylamino-6-oxopurines and Related Compounds: Structure-activity Relationships and Antiherpetic Activity In Vivo
  af: Manikowski, Andrzej, et al.
  Udgivet: (2005)