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A network of eIF2β interactions with eIF1 and Met-tRNA(i) promotes accurate start codon selection by the translation preinitiation complex

In translation initiation, a 43S preinitiation complex (PIC) containing eIF1 and a ternary complex (TC) of GTP-bound eIF2 and Met-RNA(i) scans the mRNA for the start codon. AUG recognition triggers eIF1 release and rearrangement from an open PIC conformation to a closed state with more tightly-bound...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Thakur, Anil, Marler, Laura, Hinnebusch, Alan G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411837/
https://ncbi.nlm.nih.gov/pubmed/30576497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1274
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