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A network of eIF2β interactions with eIF1 and Met-tRNA(i) promotes accurate start codon selection by the translation preinitiation complex
In translation initiation, a 43S preinitiation complex (PIC) containing eIF1 and a ternary complex (TC) of GTP-bound eIF2 and Met-RNA(i) scans the mRNA for the start codon. AUG recognition triggers eIF1 release and rearrangement from an open PIC conformation to a closed state with more tightly-bound...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6411837/ https://ncbi.nlm.nih.gov/pubmed/30576497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1274 |
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