Interactions of Eukaryotic Translation Initiation Factor 3 (eIF3) Subunit NIP1/c with eIF1 and eIF5 Promote Preinitiation Complex Assembly and Regulate Start Codon Selection

The N-terminal domain (NTD) of NIP1/eIF3c interacts directly with eIF1 and eIF5 and indirectly through eIF5 with the eIF2-GTP-Met- [Formula: see text] ternary complex (TC) to form the multifactor complex (MFC). We investigated the physiological importance of these interactions by mutating 16 segment...

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Detalhes bibliográficos
Principais autores: Valášek, Leoš, Nielsen, Klaus H., Zhang, Fan, Fekete, Christie A., Hinnebusch, Alan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC522265/
https://ncbi.nlm.nih.gov/pubmed/15485912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9437-9455.2004
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