The C-Terminal Region of Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes mRNA Recruitment, Scanning, and, Together with eIF3j and the eIF3b RNA Recognition Motif, Selection of AUG Start Codons

The C-terminal domain (CTD) of the a/Tif32 subunit of budding yeast eukaryotic translation initiation factor 3 (eIF3) interacts with eIF3 subunits j/Hcr1 and b/Prt1 and can bind helices 16 to 18 of 18S rRNA, suggesting proximity to the mRNA entry channel of the 40S subunit. We have identified substi...

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Main Authors: Chiu, Wen-Ling, Wagner, Susan, Herrmannová, Anna, Burela, Laxminarayana, Zhang, Fan, Saini, Adesh K., Valášek, Leoš, Hinnebusch, Alan G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937525/
https://ncbi.nlm.nih.gov/pubmed/20584985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00280-10
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