Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs

Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m(1)A) and 3-methylcytidine (m(3)C) demethylase of tRNA. ALKBH3 can promote cancer cell proliferation, migration and invasion. In vivo study...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Chen, Zhuojia, Qi, Meijie, Shen, Bin, Luo, Guanzheng, Wu, Yingmin, Li, Jiexin, Lu, Zhike, Zheng, Zhong, Dai, Qing, Wang, Hongsheng
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
RNA and RNA-protein complexes
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411830/
https://ncbi.nlm.nih.gov/pubmed/30541109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1250
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