ALKBH1-Mediated tRNA Demethylation Regulates Translation

Transfer RNA (tRNA) is a central component of protein synthesis and cell signaling network. One salient feature of tRNA is its heavily modified status, which can critically impact its function. Here we show that mammalian ALKBH1 is a tRNA demethylase. It mediates the demethylation of N(1)-methyladen...

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Udgivet i:Cell
Main Authors: Liu, Fange, Clark, Wesley, Luo, Guanzheng, Wang, Xiaoyun, Fu, Ye, Wei, Jiangbo, Wang, Xiao, Hao, Ziyang, Dai, Qing, Zheng, Guanqun, Ma, Honghui, Han, Dali, Evans, Molly, Klungland, Arne, Pan, Tao, He, Chuan
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119773/
https://ncbi.nlm.nih.gov/pubmed/27745969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.09.038
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