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Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding

Uridines in the wobble position of tRNA are almost invariably modified. Modifications can increase the efficiency of codon reading, but they also prevent mistranslation by limiting wobbling. In mammals, several tRNAs have 5-methoxycarbonylmethyluridine (mcm(5)U) or derivatives thereof in the wobble...

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Autors principals: Songe-Møller, Lene, van den Born, Erwin, Leihne, Vibeke, Vågbø, Cathrine B., Kristoffersen, Terese, Krokan, Hans E., Kirpekar, Finn, Falnes, Pål Ø., Klungland, Arne
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838068/
https://ncbi.nlm.nih.gov/pubmed/20123966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01602-09
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