Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein

Studies on biological functions of N(6)-methyladenosine (m(6)A) modification in mRNA have drawn significant attention in recent years. Here we describe the construction and characterization of a CRISPR–Cas13b-based tool for targeted demethylation of specific mRNA. A fusion protein, named dm(6)ACRISP...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Li, Jiexin, Chen, Zhuojia, Chen, Feng, Xie, Guoyou, Ling, Yuyi, Peng, Yanxi, Lin, Yu, Luo, Nan, Chiang, Cheng-Ming, Wang, Hongsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261189/
https://ncbi.nlm.nih.gov/pubmed/32356894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa269
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