ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another mammalian demethylase that oxidatively reverses m(6)A in mRNA in vitro and in vivo. This demethylation activity of ALKBH5 significantly affects mRNA...

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Hlavní autoři: Zheng, Guanqun, Dahl, John Arne, Niu, Yamei, Fedorcsak, Peter, Huang, Chun-Min, Li, Charles J., Vågbø, Cathrine B., Shi, Yue, Wang, Wen-Ling, Song, Shu-Hui, Lu, Zhike, Bosmans, Ralph P.G., Dai, Qing, Hao, Ya-Juan, Yang, Xin, Zhao, Wen-Ming, Tong, Wei-Min, Wang, Xiu-Jie, Bogdan, Florian, Furu, Kari, Fu, Ye, Jia, Guifang, Zhao, Xu, Liu, Jun, Krokan, Hans E., Klungland, Arne, Yang, Yun-Gui, He, Chuan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646334/
https://ncbi.nlm.nih.gov/pubmed/23177736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.015
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