ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another mammalian demethylase that oxidatively reverses m(6)A in mRNA in vitro and in vivo. This demethylation activity of ALKBH5 significantly affects mRNA...

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Main Authors: Zheng, Guanqun, Dahl, John Arne, Niu, Yamei, Fedorcsak, Peter, Huang, Chun-Min, Li, Charles J., Vågbø, Cathrine B., Shi, Yue, Wang, Wen-Ling, Song, Shu-Hui, Lu, Zhike, Bosmans, Ralph P.G., Dai, Qing, Hao, Ya-Juan, Yang, Xin, Zhao, Wen-Ming, Tong, Wei-Min, Wang, Xiu-Jie, Bogdan, Florian, Furu, Kari, Fu, Ye, Jia, Guifang, Zhao, Xu, Liu, Jun, Krokan, Hans E., Klungland, Arne, Yang, Yun-Gui, He, Chuan
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646334/
https://ncbi.nlm.nih.gov/pubmed/23177736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.015
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