ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another mammalian demethylase that oxidatively reverses m(6)A in mRNA in vitro and in vivo. This demethylation activity of ALKBH5 significantly affects mRNA...

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主要な著者: Zheng, Guanqun, Dahl, John Arne, Niu, Yamei, Fedorcsak, Peter, Huang, Chun-Min, Li, Charles J., Vågbø, Cathrine B., Shi, Yue, Wang, Wen-Ling, Song, Shu-Hui, Lu, Zhike, Bosmans, Ralph P.G., Dai, Qing, Hao, Ya-Juan, Yang, Xin, Zhao, Wen-Ming, Tong, Wei-Min, Wang, Xiu-Jie, Bogdan, Florian, Furu, Kari, Fu, Ye, Jia, Guifang, Zhao, Xu, Liu, Jun, Krokan, Hans E., Klungland, Arne, Yang, Yun-Gui, He, Chuan
フォーマット: Artigo
言語:Inglês
出版事項: 2012
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646334/
https://ncbi.nlm.nih.gov/pubmed/23177736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.015
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