DNA polymerase θ accomplishes translesion synthesis opposite 1,N(6)-ethenodeoxyadenosine with a remarkably high fidelity in human cells

Here we show that translesion synthesis (TLS) opposite 1,N(6)-ethenodeoxyadenosine (εdA), which disrupts Watson–Crick base pairing, occurs via Polι/Polζ-, Rev1-, and Polθ-dependent pathways. The requirement of Polι/Polζ is consistent with the ability of Polι to incorporate nucleotide opposite εdA by...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Genes Dev
Päätekijät: Yoon, Jung-Hoon, Johnson, Robert E., Prakash, Louise, Prakash, Satya
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2019
Aiheet:
Research Communication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411006/
https://ncbi.nlm.nih.gov/pubmed/30808656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.320531.118
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