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Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells
The action mechanisms revealed by the biochemical and structural analyses of replicative and translesion synthesis (TLS) DNA polymerases (Pols) are retained in their cellular roles. In this regard, DNA polymerase θ differs from other Pols in that whereas purified Polθ misincorporates an A opposite 1...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7196657/ https://ncbi.nlm.nih.gov/pubmed/32169903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012816 |
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