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Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells

The action mechanisms revealed by the biochemical and structural analyses of replicative and translesion synthesis (TLS) DNA polymerases (Pols) are retained in their cellular roles. In this regard, DNA polymerase θ differs from other Pols in that whereas purified Polθ misincorporates an A opposite 1...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Yoon, Jung-Hoon, Johnson, Robert E., Prakash, Louise, Prakash, Satya
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196657/
https://ncbi.nlm.nih.gov/pubmed/32169903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012816
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