DNA polymerase θ accomplishes translesion synthesis opposite 1,N(6)-ethenodeoxyadenosine with a remarkably high fidelity in human cells

Here we show that translesion synthesis (TLS) opposite 1,N(6)-ethenodeoxyadenosine (εdA), which disrupts Watson–Crick base pairing, occurs via Polι/Polζ-, Rev1-, and Polθ-dependent pathways. The requirement of Polι/Polζ is consistent with the ability of Polι to incorporate nucleotide opposite εdA by...

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Vydáno v:Genes Dev
Hlavní autoři: Yoon, Jung-Hoon, Johnson, Robert E., Prakash, Louise, Prakash, Satya
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2019
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411006/
https://ncbi.nlm.nih.gov/pubmed/30808656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.320531.118
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