Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

Genome damage and their defective repair have been etiologically linked to degenerating neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the specific mechanisms remain enigmatic. The majority of sporadic ALS patients feature abnormalities in the transactivation resp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Mitra, Joy, Guerrero, Erika N., Hegde, Pavana M., Liachko, Nicole F., Wang, Haibo, Vasquez, Velmarini, Gao, Junling, Pandey, Arvind, Taylor, J. Paul, Kraemer, Brian C., Wu, Ping, Boldogh, Istvan, Garruto, Ralph M., Mitra, Sankar, Rao, K. S., Hegde, Muralidhar L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410842/
https://ncbi.nlm.nih.gov/pubmed/30770445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818415116
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge