Chronic Oxidative Damage together with Genome Repair Deficiency in the Neurons is a Double Whammy for Neurodegeneration: Is Damage Response Signaling a Potential Therapeutic Target?

A foremost challenge for the neurons, which are among the most oxygenated cells, is the genome damage caused by chronic exposure to endogenous reactive oxygen species (ROS), formed as cellular respiratory byproducts. Strong metabolic activity associated with high transcriptional levels in these long...

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Publicado no:Mech Ageing Dev
Main Authors: Wang, Haibo, Dharmalingam, Prakash, Vasquez, Velmarini, Mitra, Joy, Boldogh, Istvan, Rao, K. S., Kent, Thomas A., Mitra, Sankar, Hegde, Muralidhar L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316312/
https://ncbi.nlm.nih.gov/pubmed/27663141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2016.09.005
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