Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity

BACKGROUND: Acetaminophen (APAP) hepatotoxicity is a major cause of acute liver failure in many countries. Mechanistic studies in mice and humans have implicated formation of a reactive metabolite, mitochondrial dysfunction and oxidant stress as critical events in the pathophysiology of APAP-induced...

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Vydáno v:J Clin Transl Res
Hlavní autoři: Xie, Yuchao, Woolbright, Benjamin L., Kos, Milan, McGill, Mitchell R., Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Jaeschke, Hartmut
Médium: Artigo
Jazyk:Inglês
Vydáno: Whioce Publishing Pte. Ltd. 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410627/
https://ncbi.nlm.nih.gov/pubmed/30873447
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