Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Nonalcoholic fatty liver disease is becoming the most common chronic liver disease in Western countries, and limited therapeutic options are available. Here we uncovered a role for intestinal hypoxia-inducible factor (HIF) in hepatic steatosis. Human-intestine biopsies from individuals with or witho...

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Vydáno v:Nat Med
Hlavní autoři: Xie, Cen, Yagai, Tomoki, Luo, Yuhong, Liang, Xianyi, Chen, Tao, Wang, Qiong, Sun, Dongxue, Zhao, Jie, Ramakrishnan, Sadeesh K, Sun, Lulu, Jiang, Chunmei, Xue, Xiang, Tian, Yuan, Krausz, Kristopher W, Patterson, Andrew D, Shah, Yatrik M, Wu, Yue, Jiang, Changtao, Gonzalez, Frank J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410352/
https://ncbi.nlm.nih.gov/pubmed/29035368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4412
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