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Temporal induction of intestinal epithelial hypoxia-inducible factor-2α is sufficient to drive colitis
Hypoxia is a notable feature of inflammatory bowel disease and chronic induction of hypoxia-inducible factor (HIF)-1α and HIF-2α (endothelial PAS domain protein 1, EPAS1) play important, but opposing, roles in its pathogenesis. While activation of HIF-1α decreases intestinal inflammation and is bene...
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| Publicado no: | Am J Physiol Gastrointest Liver Physiol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6734372/ https://ncbi.nlm.nih.gov/pubmed/31241981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00081.2019 |
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