Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty Liver

BACKGROUND & AIMS: Fatty liver or nonalcoholic fatty liver disease (NAFLD) is the most common liver disease associated with comorbidities such as insulin resistance and cardiovascular and metabolic diseases. Chronic activation of hypoxic signaling, in particular, hypoxia-inducible factor (HIF)2α...

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Veröffentlicht in:Cell Mol Gastroenterol Hepatol
Hauptverfasser: Mooli, Raja Gopal Reddy, Rodriguez, Jessica, Takahashi, Shogo, Solanki, Sumeet, Gonzalez, Frank J., Ramakrishnan, Sadeesh K., Shah, Yatrik M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258975/
https://ncbi.nlm.nih.gov/pubmed/33798787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2021.03.011
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