The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4

Flutamide (FLU), an oral, nonsteroidal antiandrogen drug used in the treatment of prostate cancer, is associated with idiosyncratic hepatotoxicity that sometimes causes severe liver damage, including cholestasis, jaundice, and liver necrosis. To understand the mechanism of toxicity, a combination of...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: Gao, Xiaoxia, Xie, Cen, Wang, Yuanyuan, Luo, Yuhong, Yagai, Tomoki, Sun, Dongxue, Qin, Xuemei, Krausz, Kristopher W., Gonzalez, Frank J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061623/
https://ncbi.nlm.nih.gov/pubmed/27569425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.08.021
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