SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. Here we combine SLAM-seq, a method for direct quantification of newly synthesized mRNAs, with pharmacological and chemical-genetic perturbation to define regulatory...

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Bibliografski detalji
Izdano u:Science
Glavni autori: Muhar, Matthias, Ebert, Anja, Neumann, Tobias, Umkehrer, Christian, Jude, Julian, Wieshofer, Corinna, Rescheneder, Philipp, Lipp, Jesse J., Herzog, Veronika A., Reichholf, Brian, Cisneros, David A., Hoffmann, Thomas, Schlapansky, Moritz F., Bhat, Pooja, von Haeseler, Arndt, Köcher, Thomas, Obenauf, Anna C., Popow, Johannes, Ameres, Stefan L., Zuber, Johannes
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409205/
https://ncbi.nlm.nih.gov/pubmed/29622725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao2793
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