Thiol-linked alkylation of RNA to assess expression dynamics

Gene expression profiling by high-throughput sequencing reveals qualitative and quantitative changes in RNA species at steady-state but obscures the intracellular dynamics of RNA transcription, processing and decay. We developed thiol(SH)-linked alkylation for the metabolic sequencing of RNA (SLAM-s...

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Bibliografiske detaljer
Udgivet i:Nat Methods
Main Authors: Herzog, Veronika A., Reichholf, Brian, Neumann, Tobias, Rescheneder, Philipp, Bhat, Pooja, Burkard, Thomas R., Wlotzka, Wiebke, von Haeseler, Arndt, Zuber, Johannes, Ameres, Stefan L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712218/
https://ncbi.nlm.nih.gov/pubmed/28945705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4435
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