SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. Here we combine SLAM-seq, a method for direct quantification of newly synthesized mRNAs, with pharmacological and chemical-genetic perturbation to define regulatory...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Science
Egile Nagusiak: Muhar, Matthias, Ebert, Anja, Neumann, Tobias, Umkehrer, Christian, Jude, Julian, Wieshofer, Corinna, Rescheneder, Philipp, Lipp, Jesse J., Herzog, Veronika A., Reichholf, Brian, Cisneros, David A., Hoffmann, Thomas, Schlapansky, Moritz F., Bhat, Pooja, von Haeseler, Arndt, Köcher, Thomas, Obenauf, Anna C., Popow, Johannes, Ameres, Stefan L., Zuber, Johannes
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409205/
https://ncbi.nlm.nih.gov/pubmed/29622725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao2793
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