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SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis
Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. Here we combine SLAM-seq, a method for direct quantification of newly synthesized mRNAs, with pharmacological and chemical-genetic perturbation to define regulatory...
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| Publicat a: | Science |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6409205/ https://ncbi.nlm.nih.gov/pubmed/29622725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao2793 |
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