SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. Here we combine SLAM-seq, a method for direct quantification of newly synthesized mRNAs, with pharmacological and chemical-genetic perturbation to define regulatory...

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Publicat a:Science
Autors principals: Muhar, Matthias, Ebert, Anja, Neumann, Tobias, Umkehrer, Christian, Jude, Julian, Wieshofer, Corinna, Rescheneder, Philipp, Lipp, Jesse J., Herzog, Veronika A., Reichholf, Brian, Cisneros, David A., Hoffmann, Thomas, Schlapansky, Moritz F., Bhat, Pooja, von Haeseler, Arndt, Köcher, Thomas, Obenauf, Anna C., Popow, Johannes, Ameres, Stefan L., Zuber, Johannes
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409205/
https://ncbi.nlm.nih.gov/pubmed/29622725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao2793
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