SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. Here we combine SLAM-seq, a method for direct quantification of newly synthesized mRNAs, with pharmacological and chemical-genetic perturbation to define regulatory...

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Publicado no:Science
Main Authors: Muhar, Matthias, Ebert, Anja, Neumann, Tobias, Umkehrer, Christian, Jude, Julian, Wieshofer, Corinna, Rescheneder, Philipp, Lipp, Jesse J., Herzog, Veronika A., Reichholf, Brian, Cisneros, David A., Hoffmann, Thomas, Schlapansky, Moritz F., Bhat, Pooja, von Haeseler, Arndt, Köcher, Thomas, Obenauf, Anna C., Popow, Johannes, Ameres, Stefan L., Zuber, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409205/
https://ncbi.nlm.nih.gov/pubmed/29622725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao2793
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