Atomistic-level study of the interactions between hIAPP protofibrils and membranes: Influence of pH and lipid composition

The pathology of type 2 diabetes mellitus is associated with the aggregation of human islet amyloid polypeptide (hIAPP) and aggregation-mediated membrane disruption. The interactions of hIAPP aggregates with lipid membrane, as well as the effects of pH and lipid composition at the atomic level, rema...

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Bibliographic Details
Published in:Biochim Biophys Acta Biomembr
Main Authors: Qian, Zhenyu, Zou, Yu, Zhang, Qingwen, Chen, Peijie, Ma, Buyong, Wei, Guanghong, Nussinov, Ruth
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408309/
https://ncbi.nlm.nih.gov/pubmed/29428499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2018.02.005
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